More than 8 million babies born from IVF since the world’s first in 1978

Forty years after the birth of Louise Brown, the world’s first test-tube baby, an international committee monitoring progress in assisted reproduction reports today that the global total of babies born as a result of IVF and other advanced fertility treatments is “more than 8 million”. Dr. David Adamson speaking at this congress on behalf of the International Committee for Monitoring ART (ICMART) said: “Based on ICMART’s annual collection of global IVF data, it is estimated that since Louise Brown’s birth in 1978 over 8 Million babies have been born from IVF around the world.”

The figure, calculated from data collected from regional registries from 1991 to 2014, represent another steep rise in the cumulative use of IVF in the treatment of infertility. Estimates are that more than a half million babies are now born each year from IVF and ICSI from more than 2 million treatment cycles performed.

In Europe, Spain remains the most active country in assisted reproduction. ESHRE has collected the national registry data of ART cycles performed in Europe since 1997 and for its latest report (for 2015) found that a record 119,875 treatment cycles were performed in Spain, which now sets the pace of European treatment ahead of Russia (110,723 cycles), Germany (96,512) and former front runner France (93.918). The cycles monitored by ESHRE include treatments with IVF, ICSI, and egg donation.

The report covers a total of almost 800,000 treatment cycles performed in 2015 and 157,449 babies born—and represents the largest and most accurate snapshot of ART in Europe. Dr. Christian de Geyter, chairman of ESHRE’s European IVF Monitoring Consortium, will present the results today in Barcelona at the 34th Annual Meeting of ESHRE.

Dr. de Geyter estimates that around 80% of all European assisted reproduction fertility treatments are included in the monitoring programme—but this year (ie, for 2015) without the data so far from the UK. The UK usually performs around 60,000 treatments a year.

Among other findings:

• Clinics in Europe continue to favour ICSI over IVF by around two-to-one (356,351 ICSI, 131,221 IVF), a pattern now evident throughout the world. ICSI was developed in the early 1990s as a specific treatment for male infertility (low sperm counts, poor sperm quality) but is now clearly used for fertilisation in non-male cases.
• Pregnancy rates (as measured per embryo transfer) seem to have stabilised in Europe at about 36% for both IVF and ICSI. Pregnancy rates are higher with five-day old embryos (blastocysts) than with three-day.
• Pregnancy rates from egg donation continue to rise (now at about 50%).
• The rate of twin pregnancy continues to decline in Europe, in 2015 to around 14%. Similarly, the rate of single embryo transfers continues to rise—from 11% in 1997 to 38% in 2015.

“Success rates have stabilised,” said ESHRE’s EIM committee chairman Christian De Geyter, “although outcome in egg donation and with use of frozen embryos is still moving upwards. The biggest upwards movement, however, is from treatments with frozen eggs, which have been revolutionised by the widespread introduction of vitrification.”

Also gaining ground is embryo freezing. All embryos in 15% of all treatment cycles monitored in 2015 were frozen before thawing and transfer in a subsequent cycle. Uptake of this “freeze-all” approach increased by 7% on the previous year. Freezing by vitrification would also explain the increase in egg donation treatments, no doubt made possible by egg banking and the greater availability of donor eggs.

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