First-in-human study with novel antisense oligonucleotide proves promising

A single intravenous dose of MRG-110, an anti-microRNA drug, significantly reduced miR-92a levels in the blood of healthy humans. Inhibition of miR-92a has shown beneficial effects in animal models, including improved vascularization after myocardial infarction, and accelerated wound healing, according to the peer-reviewed journal Nucleic Acid Therapeutics.

“Based on documented, promising therapeutic potential, locked nucleic acid (LNA)-based anti-miR-92a was further developed and tested in a first in human study,” said Stefanie Dimmeler, Ph.D., Goethe University, Frankfurt, Germany and coauthors. “MRG-110 caused de-repression of gene targets in human peripheral blood cells.”

Source: Read Full Article