Alzheimer’s disease: increasing, lack of sleep, the Protein deposits in the brain
Can protect a sufficient sleep before Alzheimer’s?
Researchers found out now that lack of sleep accelerates the spread of toxic aggregates of Tau-Protein solid. These accumulations are a harbinger of brain damage and a crucial step on the way to the development of dementia.
The scientists from the Washington University found in their recent study that lack of sleep enhances the development of dementia. The doctors published the results of their study in the English journal “Science”.
Sleep is important
Sleep disorders are already brought for a long time with Alzheimer’s disease. So far, however, only little is known about how exactly occurring sleep disorders are driving the disease. The new study, humans and mice showed that the sleep deprivation, the concentration of the for Alzheimer’s, the important thaw increases Protein. In other succession studies on mice, the experts were able to find that insomnia also accelerates the spread of toxic Tauklumpen in the brain.
Lack of sleep and its consequences
The researchers explain that a lack of sleep drives the development of the disease. This background suggested that healthy sleep can maintain the health of the brain. What is interesting about this study is that real-world factors, such as the sleep can have an impact on how quickly the disease spreads in the brain, explained study author Dr. David Holtzman of Washington University School of Medicine. Sleep disorders and Alzheimer’s disease were brought to a part also on a different Alzheimer’s Protein (Amyloid Beta). This study, however, shows that sleep disorders, especially the harmful Tau Protein increase rapidly and spread, adds the expert.
The disease process can be delayed by sleep and slows down
The brain needs time to recover from the Stress of the day. It is not yet clear whether adequate sleep protects aging people really Alzheimer’s, explain the doctors. But enough sleep can’t hurt, and these and other data suggest that sleep may even help to delay the disease process and slow down, if he has already started.
What is the significance of sleeping for the build-up of Tau?
Tau is also found in the brain of healthy people, but under certain conditions it can lead to accumulations, the near-lying tissue injury, and a cognitive decline. The results of the investigation show that the amount of dew sleeping people in the elderly poor increases. However, it was not clear whether the lack of sleep increases the concentration of Tau directly, or whether sleep and the amount of Tau are associated in any other way. For the study, the researchers measured Tau levels in mice and humans with normal and disturbed sleep. Mice are active at night, and the experts noted that the Tau concentration in the fluid that surrounds the brain cells, was at night, about twice as high if the animals were more awake and active, compared with values of Tau in the day when the mice were resting.
A sleepless night increased the Tau value of about 50 percent
The same effect was also observed in humans. The physicians examined the so-called Cerebro-spinal fluid of eight subjects after a night in which the Participating normal had slept. The experiment was repeated, after the people have been kept a whole night awake. Through a sleepless night, the dew rose in value by about 50 percent. All in all, the findings suggest that Tau is set during the waking hours of the day, routinely through the normal way of Thinking and Acting. The release of Tau is reduced during sleep, so that Tau can be degraded. Sleep deprivation among these cycle breaks down, causing the Tau build and it is more likely that the Protein accumulates into harmful clumps.
Tau is built in the memory of the important Parts
In people with Alzheimer’s disease, so-called Tau Tangles tend to be in the memory of the important Parts of the brain to build up the Hippocampus and the entorhinal cortex. From there, they spread to other regions of the brain. If Tau spreads and more and more areas of the brain are affected, it is Affected more and more difficult to think clearly. In order to investigate whether the spread of Tau Tangles is affected by sleep, gave the researchers the Hippocampi of mice with tiny Tauklumpen and kept the animals every day for long periods of time awake. A separate group of mice were injected with Tau clumps, the animals but were allowed to sleep whenever they wanted. After four weeks, the Tau accumulations were spread in the sleepless mice more than in the dormant animals.
